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Sami Haddad

Fonction	Professeur agrégé, Département de santé environnementale et santé au travail, Faculté de médecine, Université de Montréal Chercheur régulier, IRSPUM Responsable du regroupement thématique majeur Environnements et santé, IRSPUM
Unités	Institut de recherche en santé publique de l'Université de Montréal Santé Environnementale et Santé au Travail
Regroupement thématique majeur	Environnements et santé
Formation	Ph.D. Santé publique (Université de Montréal) M.Sc. Hygiène du travail et de l'environnement (Université de Montréal) B.Sc. Biochimie (Université McGill)
Champs d'intérêt	Identification et modélisation d’interactions entre xénobiotiques dans les mélanges (polluants et médicaments). Extrapolations in vitro-in vivo des interactions toxicocinétiques Modélisation à base physiologique de la toxicocinétique des polluants. Développement et application de modéles toxicocinétiques à base physiologique pour l’estimation de l’exposition dans les études épidémiologiques. Expositions par inhalation.
Mots-clés	Physiologically-based pharmacokinetic modeling; Biomathematical model development and validation; Bioinformatics; Pharmacokinetics; PBPK modeling; In vitro-in vivo extrapolations in phamracokinetics and metabolism.
Adresse postale	Département de Santé environnementale et santé au travail Université de Montréal C.P. 6128, succ. Centre-Ville Montréal (Québec), H3C 3J7 Canada
Adresse civique	Département de Santé environnementale et santé au travail Université de Montréal Pavillon Marguerite d'Youville 2375, chemin de la Côte-Sainte-Catherine, bureau 7085 Montréal (Québec), H3T 1A8 Canada
Téléphone	514 343-6111, poste 38166
Télécopieur	(514) 343-2200
Courriel
Site Web	http://www.dsest.umontreal.ca/bottin/professeurs_chercheurs/sami_haddad.html

Publications associées

Articles avec comité de lecture, publiés (42 titres)

ÉquiNanos: innovative team for nanoparticle risk management 2013

Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children 2013

Modulation of trichloroethylene in vitro metabolism by different drugs in rats 2013

Toxicokinetic Modeling of Persistent Organic Pollutant Levels in Blood from Birth to 45 Months of Age in Longitudinal Birth C[...] 2013

Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissu[...] 2012

Comparative assessment of In Vitro–In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs [...] 2012

In vitro effects of PCDDs/Fs on NK-like cell activity of Eisenia andrei earthworms 2012

In Vitro–In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Ass[...] 2012

Toxic effects of PCDD/Fs mixtures on Eisenia andrei earthworms 2012

A Case Study Addressing the Reliability of Polychlorinated Biphenyl Levels Measured at the Time of Breast Cancer Diagnosis in[...] 2011

Effects of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans on phagocytic response of Eisenia andrei coelo[...] 2011

In vitro Neurotoxicity Data in Human Risk Assessement of Polybrominated Diphenyl Ethers (PDBEs): Overview and Perspectives [...] 2011

Microsome Composition-Based Model as a Mechanistic Tool to Predict Nonspeciﬁc Binding of Drugs in Liver Microsome [...] 2011

Alteration of infant attention and activity by polychlorinated biphenyls: Unravelling critical windows of susceptibility usin[...] 2010

Assessment of exposure to persistent organochlorine compounds in epidemiological studies on breast cancer: a literature revie[...] 2010

Extrapolating in vitro metabolic interactions to isolated perfused liver: Predictions of metabolic interactions between R-buf[...] 2010

High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats 2010

Oral p-Tert-Octylphenol Exposures Induce Minimal Toxic or Estrogenic Effects in Adult Female Sprague-Dawley Rats 2010

Physiologically based modeling of p-tert-octylphenol kinetics following intravenous, oral or subcutaneous exposure in male an[...] 2010

A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epide[...] 2009

Effects of Chronic Exposure to Octylphenol on the Male Rat Reproductive System 2009

Toxicokinetics of p-tert-Octylphenol in Male and Female Sprague-Dawley Rats After Intravenous, Oral, or Subcutaneous Exposure[...] 2009

Determination of p-tert-octylphenol in blood and tissues by gas chromatography coupled with mass spectrometry 2008

Physiologically Based Pharmacokinetic Modeling of Persistent Organic Pollutants for Lifetime Exposure Assessment: A New Tool [...] 2008

Development of a physiologically based toxicokinetic models for improving the human indoor exposure assessment to water cont[...] 2006

Physiologically modeling of age-specific changes in the pharmacokinetics of volatile organic chemicals 2003

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection 2003

Physiological modeling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures. 2002

A PBPK Modeling-Based Approach to Account for Interactions in the Health Risk Assessment of Chemical Mixtures 2001

Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans 2001

Physiological Modeling of the Toxicokinetic Interactions in a Quaternary Mixture of Aromatic Hydrocarbons 2000

Physiologically based modeling of the maximal effect of metabolic interactions on the kinetics of components of complex chemi[...] 2000

Relative lipid content as the sole mechanistic determinant of the adipose tissue:blood partition coefficients of highly lipop[...] 2000

Validation of a Physiological Modeling Framework for Simulating the Toxicokinetics of Chemicals in Mixtures 2000

A modeling approach for predicting the biological hazard index of chemical mixtures 1999

Physiological modeling of pharmacokinetic interaction in a quaternary mixture of hydrocarbons 1999

Physiological modeling of toxicokinetic interactions: implications for mixture risk assessment 1998

Physiologically-based pharmacokinetic modeling of pyrene in the rat 1998

Rate of pyrene metabolism in rat liver post-mitochondrial fractions 1997

A methodology for solving physiologically-based pharmacokinetic models without the use of simulation softwares 1996

A simple index for representing the discrepancy between simulations of physiological pharmacokinetic models and experimental [...] 1995

Statistical approaches for the validaion of physiologically based pharmacokinetic models. 1995

Chapitre de livre (6 titres)

Physiologically‑Based Pharmacokinetic (PBPK) Models in Toxicity Testing and Risk Assessment 2012

Modeling the exposure to disinfection by-products (DBPs) 2011

Physiologically Based Modeling of Pharmacokinetic Interactions in Chemical Mixtures 2010

Toxicokinetics and Toxicodynamics 2010

In silico predictions of partition coefficients and the application of PBPK modeling to assess interindividual variance 2006

Applications of Genomics in Immunotoxicology 2005

Rapports de recherche (5 titres)

Évaluation des niveaux d’éthanolémie résultant de l’exposition à l’éthanol par inhalation : études chez des volontaires et mo[...] 2012

Modélisation pharmacocinétique à base physiologique des polluants de l'eau potable 2004

Using a novel PBPK model for the liver as a tool for in vitro-in vivo extrapolations of metabolic interactions: predictions o[...] 2002

A physiologically-based pharmacokinetic model for the liver as a tool for in vitro-in vivo extrapolations: (1) Model developm[...] 2001

A physiologically-based pharmacokinetic model for the liver as a tool for in vitro-in vivo extrapolations: 2. Hepatic clearan[...] 2001

Conférences scientifiques (96 titres)

Assessment of blood levels of Ethanol resulting from ethanol exposure by inhalation: studies in volunteers and tocicokinetic [...] 2012

Évaluation des niveaux d’éthanolémie résultant de l’exposition à l’éthanol par inhalation : Étude chez des volontaitres et mo[...] 2012

In vivo toxicokinetic interactions between three medicinal drugs and trichloroethylene in rat 2012

Climate Change and Increased Precipitations: The Impact of Heavy Rainfalls on Surface Water Total Organic Carbon (TOC) and Re[...] 2011

Développement d'un modèle pharmacocinétique à base physiologique pour les polluants organiques persistants et son application[...] 2011

Drugs interacting with trichloroethylene metabolism in rat and human 2011

Persistence of behavioural impairment by pre‐and postnatal exposure to polychlorinated biphenyls (PCBs) 2011

Pharmaceutical drugs and their impact on chemical toxicological risk assessment 2011

Pharmacokinetic and Pharmacodynamic Mechanisms of interactions in Mixtures 2011

Validation of a Pharmacokinetic Model of Polychlorinated Biphenyls (PCBs) Using Blood Levels in Children from Birth up to 22 [...] 2011

Comparison of Estimated PCB-153 Concentrations in Human Milk Using Various Pharmacokinetic Models 2010

Drugs potentially affecting trichloroethylene metabolism 2010

Drug-Trichloroethylene Pharmacokinetic interactions 2010

Estimation of Postnatal Internal Exposure to Organochlorine Compounds in the INMA-Sabadell Birth Cohort (Spain) 2010

Internal Doses of PCB153 Estimated for Different Exposure Windows During Women's Lifetime are Inversely Associated With the I[...] 2010

L'altération de l'attention et du Contrôle de l'activité chez les Enfants Exposés au Biphényles Polychlorés (BPC) 2010

Quand les Organochlorés Sanguins Renient leur Passé: Évaluation des Erreurs de Classification dans les Études Épidémiologique[...] 2010

Unveiling associations between lactational exposure to polychlorinated biphenyls (PCBs) and infant neurodevelopment: use of P[...] 2010

What Do Late-life Polychlorinated Biphenyls (PCB) Levels Tell us on Lifetime Internal Exposure? An Evaluation of Exposure Mis[...] 2010

A PBPK modeling tool to predict infant internal exposure to persistant organic chemicals and assess critical periods of susce[...] 2009

Effets d'un mélange de dioxines sur la réponse immunitaire chez le ver de terre eisenia andrei 2009

Identification de médicaments interagissant sur la génotoxicité du benzo[a]pyrène 2009

Impairment of Infant Behaviour by Polychlorinated Biphenyls (PCBs): Physiologically-based Pharmacokinetic (PBPK) Modeling Rev[...] 2009

In vitro characterization of metabolic interactions between n-hexane, toluene cyclohexane and isooctane 2009

Interactions between human pharmaceuticals and environmental chemicals: Occurrence and mechanisms 2009

Organochlorine residues in breast milk of Inuit mothers 2009

PBPK modeling of an alkylbenzene mixture in neonates: evaluation of the relative contribution of inhalation and lactational t[...] 2009

Pharmacokinetic interactions between bisphenol A and naproxen in humans 2009

A PBPK modeling approach for in vitro-in vivo extrapolation of drug-drug metabolic interactions 2008

A physicologically-based phrmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epide[...] 2008

Drug Interference with biotransformation of Bisphenol A and Nonyl-phenol in Rats 2008

Physiologically-Based Pharmacokinetic Modeling of an Alkylbenzene Mixture in Children of Various Age Groups 2008

A PBPK modeling approach for in vitro-in vivo extrapolation of drug-drug metabolic interactions 2007

Evaluating the potential impact of p-tert-octylphenol on the kinetics of oestradiol in the rat 2007

Evaluation of Adult-Neonate Diffference in Metabolic Interactions Among Alkyl Benzenes (ABS) Using a Mixture PBPK Model 2007

Identification d'interactions métaboliques entre certains médicaments et le nonylphénol 2007

La biotransformation du nonylphénol et du bisphénol A peut être inhibée par plusieurs médicaments chez le rat 2007

Mechanistic simulation tool for lifetime internal exposure to persistent organic pollutants (POP) 2007

PBPK modeling of metabolic interactions: extrapolating from binary to more complex mixtures 2007

Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool [...] 2007

Physiologically-based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment 2007

Statistical Approaches for Evaluation of Physiologically Based Pharmacokinetic (PBPK) Models 2007

Extrapolation i.v.-oral de la toxicocinétique du 4-tert-octylphénol chez le rat femelle 2006

Modeling exposure to THMs: a multidisicplinary approach integrating envrionmental occurrence and toxicokinetic profile 2006

Modeling Exposure to Trihalomethanes: A Multidisciplinary Approach Integrating Environmental Occurrence and Toxicokinetic P[...] 2006

Modélisation de l’exposition aux trihalométhanes : combiner données environnementales et approche toxicologique dans une tram[...] 2006

Modélisation PBPK des interactions métaboliques chez l'enfant exposé à un mélange d'alkylbenzènes 2006

Modélisation pharmacocinétique à base physiologique (PCBP) des polluants organiques persistants (POP) comme outil dans l'étud[...] 2006

Persistant organic pollutants in breast cancer epidemiological studies: a physiologically based pharmacokinetic modeling fram[...] 2006

Statistical validation of physiologically based pharmacokinetic models 2006

The use of a physiologically based modeling approach for assessing the machanisms of p-tert-optylphenol toxicokinetics in the[...] 2006

Modélisation de l’exposition aux trihalométhanes : combiner données environnementales et approche toxicologique dans une tram[...] 2005

Modélisation toxicocinétique de l’exposition multimédia à des contaminants de l’eau potable 2005

Modélisation toxicocinétique de l'exposition multimédia à des contaminants de l'eau potable 2005

Utilisation d'une approche de modélisation à base physiologique pour l'évaluation des mécanisme toxicocinétique de l'octylphé[...] 2005

Modélisation à base physiologique pour une meilleure compréhension de la toxicologie des xénobiotiques: Innovation et applica[...] 2004

PBPK modeling and extrapolation of pharmacokinetics interactions from simple to complex mixtures. 2000

A modeling approach to account for toxicokinetic interactions in the calculation of biological hazard index for chemical mixt[...] 1999

Development of an unified approach for predicting bioconcentration of organic chemicals in humans and fish. 1999

Health risk assessment based on physiological modeling of pharmacokinetic interactions in chemical mixtures 1999

Modélisation toxicocinétique à base physiologique de mélanges complexes 1999

PBPK models in risk assessment 1999

Physiological modeling of multichemical interactions in complex mixtures 1999

Physiological modeling to characterize adult-children differences in pharmacokinetics. 1999

Une nouvelle méthode d'analyse de risque tenant compte des interactions, applicable à des mélanges de contaminants chimiques. 1999

A generic physiological model for simulating the toxicokinetics of polycyclic aromatic hydrocarbons. 1998

A methodology for conducting interactions-based risk assessment of chemical mixtures. 1998

A methodology for conducting interactions-based risk assessment of chemical mixtures. 1998

A modeling approach for toxicokinetic interactions in the calculation of biological hazard index for chemical mixtures. 1998

A tissue composition-based algorithm for predicting bioconcentration of organic chemicals in rainbow trout. 1998

Adjusting for toxicokinetic differences in the derivation of toxic equivalency factors for mixture risk assessment. 1998

An interactions-base physiological toxicokinetic model for chemical mixtures. 1998

An interactions-base physiological toxicokinetic model for chemical mixtures. 1998

An interactions-based mixture risk assessment methodology for systemic toxicants. 1998

Evaluation of the binary level interactions in a quaternary mixture of aromatic hydrocarbons. 1998

Modeling of bioaccumulation of organic compounds in fish. 1998

Molecular structure-based prediction of bioconcentration factors of organic chemicals in fish. 1998

PBPK models in risk assessment 1998

Physiological modeling of higher order metabolic interactions in complex chemical mixtures. 1998

Physiological modeling of the toxicokinetic interactions in a quaternary mixture of volatile organic chemicals. 1998

A mechanistic algorithm for predicting bioconcentration factors of organic chemicals in fish. 1997

Adjusting for phamacokinetic differences in the toxic equivalency factor approach for mixture risk assessment. 1997

An approach for predicting fish bioconcentration factors of chemicals from their molecular structure. 1997

Influence de l'exposition simultanée aux solvants aromatiques sur la cinétique sanguine du dichlorométhane chez le rat. 1997

Modélisation pharmacocinétique à base physiologique du pyrène. 1997

Physiological modeling of toxicokinetic interactions in a quaternary mixture of volatile organic chemicals. 1997

Physiologically-based pharmacokinetic modeling of a quaternary mixture of volatile organic chemicals 1997

Refining the toxic equivalency factor approach for mixture risk assessment based on pharmacokinetic considerations. 1997

Toxicokinetic interactions between dichloromethane and alkylbenzenes in the rat. 1997

Toxicokinetic interactions between dichloromethane and alkylbenzenes in the rat. 1997

An unified algorithm for predicting bioconcentration factors of organic chemicals in fish 1996

Computer modeling of chemical disposition in farm animals 1996

Determination of the rate of pyrene and 1-hydroxypyrene metabolism in the rat liver post-mitochondrial fraction 1996

Physiological pharmacokinetics of pyrene in the rat 1996

Development of methodologies for the validation of physiologically-based pharmacokinetic models 1995

Physiological pharmacokinetics of pyrene in the rat. 1966

Autres communications (1 titre)

Refining exposure assessment of persistent organic pollutants with the use of physiologically based pharmacokinetic modeling 2011

Projets courants affiliés à l'IRSPUM

Identification of drug-pollutant interactions and refining predictions of interindividual variability in pollutant toxicokine[...]2010
Conseil de Recherche en Sci Nat et en genie du Canà 2015
NGG01252

Laboratoire sur les interactions toxicologiques dans les mélanges de xénobiotiques - Fonds des leaders2011
Fondation canadienne pour l'innovationà 2014
NGG01422

Évaluation de l'exposition des travailleurs aux sous-produits de désinfection en piscine au Québec2011
Institut de recherche Robert-Sauvé en santé et en sécurité du travailà 2014
NGG01735

Improving interpretation of biomonitoring data for volatile chemical mixtures using physiologically-based pharmacokinetic mod[...]2011
Santé Canadaà 2014
R0019645